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Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women

Bradshaw, Catriona S.; Walker, Jennifer; Fairley, Christopher K.; Chen, Marcus Y.; Tabrizi, Sepehr N.; Donovan, Basil; Kaldor, John M.; McNamee, Kathryn; Urban, Eve; Walker, Sandra; Currie, Marian; Birden, Hudson; Bowden, Francis; Garland, Suzanne; Pirotta, Marie; Gurrin, Lyle; Hocking, Jane S.

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BACKGROUND To determine prevalence and incidence of bacterial vaginosis (BV) and risk factors in young sexually-active Australian women. METHODS 1093 women aged 16-25 years were recruited from primary-care clinics. Participants completed 3-monthly questionnaires and self-collected vaginal smears 6-monthly for 12-months. The primary endpoint was a Nugent Score = 7-10 (BV) and the secondary endpoint was a NS = 4-10 (abnormal flora [AF]). BV and AF prevalence estimates and 95% confidence intervals...[Show more]

dc.contributor.authorBradshaw, Catriona S.
dc.contributor.authorWalker, Jennifer
dc.contributor.authorFairley, Christopher K.
dc.contributor.authorChen, Marcus Y.
dc.contributor.authorTabrizi, Sepehr N.
dc.contributor.authorDonovan, Basil
dc.contributor.authorKaldor, John M.
dc.contributor.authorMcNamee, Kathryn
dc.contributor.authorUrban, Eve
dc.contributor.authorWalker, Sandra
dc.contributor.authorCurrie, Marian
dc.contributor.authorBirden, Hudson
dc.contributor.authorBowden, Francis
dc.contributor.authorGarland, Suzanne
dc.contributor.authorPirotta, Marie
dc.contributor.authorGurrin, Lyle
dc.contributor.authorHocking, Jane S.
dc.date.accessioned2015-11-24T23:36:01Z
dc.date.available2015-11-24T23:36:01Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/16699
dc.description.abstractBACKGROUND To determine prevalence and incidence of bacterial vaginosis (BV) and risk factors in young sexually-active Australian women. METHODS 1093 women aged 16-25 years were recruited from primary-care clinics. Participants completed 3-monthly questionnaires and self-collected vaginal smears 6-monthly for 12-months. The primary endpoint was a Nugent Score = 7-10 (BV) and the secondary endpoint was a NS = 4-10 (abnormal flora [AF]). BV and AF prevalence estimates and 95% confidence intervals (95%CI) were derived, and adjusted odds ratios (AOR) calculated to explore epidemiological associations with prevalent BV and AF. Proportional-hazards regression models were used to examine factors associated with incident BV and AF. RESULTS At baseline 129 women had BV [11.8% (95%CI: 9.4-14.2)] and 188 AF (17.2%; 15.1-19.5). Prevalent BV was associated with having a recent female partner [AOR = 2.1; 1.0-4.4] and lack of tertiary-education [AOR = 1.9; 1.2-3.0]; use of an oestrogen-containing contraceptive (OCC) was associated with reduced risk [AOR = 0.6; 0.4-0.9]. Prevalent AF was associated with the same factors, and additionally with >5 male partners (MSP) in 12-months [AOR = 1.8; 1.2-2.5)], and detection of C.trachomatis or M.genitalium [AOR = 2.1; 1.0-4.5]. There were 82 cases of incident BV (9.4%;7.7-11.7/100 person-years) and 129 with incident AF (14.8%; 12.5-17.6/100 person-years). Incident BV and AF were associated with a new MSP [adjusted rate ratio (ARR) = 1.5; 1.1-2.2 and ARR = 1.5; 1.1-2.0], respectively. OCC-use was associated with reduced risk of incident AF [ARR = 0.7; 0.5-1.0]. CONCLUSION This paper presents BV and AF prevalence and incidence estimates from a large prospective cohort of young Australian women predominantly recruited from primary-care clinics. These data support the concept that sexual activity is strongly associated with the development of BV and AF and that use of an OCC is associated with reduced risk.
dc.description.sponsorshipThis work was supported by the Commonwealth of Australia, as part of a National Chlamydia Pilot Program and the Australian National Health and Research Council (research grant number 509144). CSB, and JSH were supported by research fellowships issued by the Australian National Health and Medical Research Council (fellowship numbers 456164 and 566576 respectively). MP was supported by a Primary Health Care Research Evaluation and Development MidCareer Fellowship, Department of Health and Aging.
dc.format8 pages
dc.publisherPublic Library of Science
dc.rights© 2013 Bradshaw et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS ONE
dc.subjectadolescent
dc.subjectadult
dc.subjectaustralia
dc.subjectcohort studies
dc.subjectfemale
dc.subjecthumans
dc.subjectincidence
dc.subjectprevalence
dc.subjectproportional hazards models
dc.subjectrisk factors
dc.subjectsexual partners
dc.subjectvaginosis, bacterial
dc.subjectyoung adult
dc.subjectcontraception behavior
dc.subjectsexual behavior
dc.titlePrevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume8
dcterms.dateAccepted2013-01-24
dc.date.issued2013-03-05
local.identifier.absfor111717
local.identifier.absfor119999
local.identifier.ariespublicationf5625xPUB2565
local.publisher.urlhttps://www.plos.org/
local.type.statusPublished Version
local.contributor.affiliationBradshaw, Catriona, University of Melbourne, Australia
local.contributor.affiliationWalker, Jennifer , University of Melbourne, Australia
local.contributor.affiliationFairley, Christopher K, Melbourne Sexual Health Centre, Australia
local.contributor.affiliationChen, Marcus Y, University of Melbourne, Australia
local.contributor.affiliationTabrizi, Sepehr, Royal Women's Hospital, Australia
local.contributor.affiliationDonovan, Basil, University of New South Wales, Australia
local.contributor.affiliationKaldor, John M, University of New South Wales, Australia
local.contributor.affiliationMcNamee, Kathryn, Family Planning Victoria, Australia
local.contributor.affiliationUrban, Eve , University of Melbourne, Australia
local.contributor.affiliationCurrie, Marian, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.contributor.affiliationWalker, Sandra M , University of Melbourne, Australia
local.contributor.affiliationBirden, Hudson, University of Sydney, Australia
local.contributor.affiliationBowden, Francis, College of Medicine, Biology and Environment, CMBE ANU Medical School, ANU Medical School, The Australian National University
local.contributor.affiliationGarland, Suzanne, University of Melbourne, Australia
local.contributor.affiliationPirotta, Marie , University of Melbourne, Australia
local.contributor.affiliationGurrin, Lyle C., University of Melbourne, Australia
local.contributor.affiliationHocking, Jane S, University of Melbourne, Australia
dc.relationhttp://purl.org/au-research/grants/nhmrc/509144
dc.relationhttp://purl.org/au-research/grants/nhmrc/456164
dc.relationhttp://purl.org/au-research/grants/nhmrc/566576
local.identifier.essn1932-6203
local.bibliographicCitation.issue3
local.bibliographicCitation.startpagee57688
local.bibliographicCitation.lastpage8
local.identifier.doi10.1371/journal.pone.0057688
dc.date.updated2015-12-11T07:34:03Z
local.identifier.scopusID2-s2.0-84874632404
CollectionsANU Research Publications

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