Investigating the mechanism underlying the nucleolar surveillance pathway in disease
The nucleolus is not only a hub for ribosome biogenesis, but also a sensor of cellular stress. When the nucleolus detects stress (e.g. ribosome biogenesis perturbations), it activates the 'nucleolar surveillance pathway' (NSP) which maybe dependent/independent of p53. Perturbed ribosome biogenesis is also associated with diseases such as cancer and ribosomopathies (diseases of the ribosome). Diamond-Blackfan Anaemia (DBA) is a rare blood cell aplasia that presents clinically at approximately...[Show more]
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