Skip navigation
Skip navigation

Investigating the mechanism underlying the nucleolar surveillance pathway in disease

Nunez Villacis, Lorena

Description

The nucleolus is not only a hub for ribosome biogenesis, but also a sensor of cellular stress. When the nucleolus detects stress (e.g. ribosome biogenesis perturbations), it activates the 'nucleolar surveillance pathway' (NSP) which maybe dependent/independent of p53. Perturbed ribosome biogenesis is also associated with diseases such as cancer and ribosomopathies (diseases of the ribosome). Diamond-Blackfan Anaemia (DBA) is a rare blood cell aplasia that presents clinically at approximately...[Show more]

CollectionsRestricted Theses
Date published: 2019
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/166999
DOI: 10.25911/5da04d2a8c6d1
Embargoed until: 2021-10-11

Download

File SizeFormat  
Revised Thesis_Full confidentiality.pdf4.62 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator