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A Conserved Mammalian Protein Interaction Network

Pérez-Bercoff, Åsa; Hudson, Corey M.; Conant, Gavin C.


Physical interactions between proteins mediate a variety of biological functions, including signal transduction, physical structuring of the cell and regulation. While extensive catalogs of such interactions are known from model organisms, their evolutionary histories are difficult to study given the lack of interaction data from phylogenetic outgroups. Using phylogenomic approaches, we infer a upper bound on the time of origin for a large set of human protein-protein interactions, showing that...[Show more]

CollectionsANU Research Publications
Date published: 2013-01-02
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0052581


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