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In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1

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Nishimoto, Masazumi; Katano, Miyuki; Yamagishi, Toshiyuki; Hishida, Tomoaki; Kamon, Masayoshi; Suzuki, Ayumu; Hirasaki, Masataka; Nabeshima, Yoko; Nabeshima, Yo-ichi; Katsura, Yukako; Satta, Yoko; Deakin, Janine E.; Graves, Jennifer A. Marshall; Kuroki, Yoko; Ono, Ryuichi; Ishino, Fumitoshi; Ema, Masatsugu; Takahashi, Satoru; Kato, Hidemasa; Okuda, Akihiko

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Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal...[Show more]

dc.contributor.authorNishimoto, Masazumi
dc.contributor.authorKatano, Miyuki
dc.contributor.authorYamagishi, Toshiyuki
dc.contributor.authorHishida, Tomoaki
dc.contributor.authorKamon, Masayoshi
dc.contributor.authorSuzuki, Ayumu
dc.contributor.authorHirasaki, Masataka
dc.contributor.authorNabeshima, Yoko
dc.contributor.authorNabeshima, Yo-ichi
dc.contributor.authorKatsura, Yukako
dc.contributor.authorSatta, Yoko
dc.contributor.authorDeakin, Janine E.
dc.contributor.authorGraves, Jennifer A. Marshall
dc.contributor.authorKuroki, Yoko
dc.contributor.authorOno, Ryuichi
dc.contributor.authorIshino, Fumitoshi
dc.contributor.authorEma, Masatsugu
dc.contributor.authorTakahashi, Satoru
dc.contributor.authorKato, Hidemasa
dc.contributor.authorOkuda, Akihiko
dc.date.accessioned2015-11-24T06:00:33Z
dc.date.available2015-11-24T06:00:33Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/16674
dc.description.abstractEmbryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal cells at least in part contributed to this phenotype. We also found that the effects of loss of UTF1 expression in embryonic stem cells on their pluripotency were very subtle. Genome structure and sequence comparisons revealed that the UTF1 gene exists only in placental mammals. Our analyses of a family of genes with homology to UTF1 revealed a possible mechanism by which placental mammals have evolved the UTF1 genes.
dc.description.sponsorshipThis study was supported in part by the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT), and mostly by the Support Program for the Strategic Research Foundation at Private Universities, 2008–2012. This study was performed as a part of the Core Research for Evolutional Science and Technology (CREST) Agency. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.publisherPublic Library of Science
dc.rights© 2013 Nishimoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS ONE
dc.subjectamino acid sequence
dc.subjectanimals
dc.subjectchromosomal proteins, non-histone
dc.subjectembryonic development
dc.subjectembryonic stem cells
dc.subjectevolution, molecular
dc.subjectfemale
dc.subjectgene knockout techniques
dc.subjectgene targeting
dc.subjectgenotype
dc.subjectmice
dc.subjectmolecular sequence data
dc.subjectmutation
dc.subjectphenotype
dc.subjectphylogeny
dc.subjectplacenta
dc.subjectpregnancy
dc.subjectsequence alignment
dc.subjecttrans-activators
dc.titleIn Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume8
dc.date.issued2013-07-09
local.identifier.absfor060399
local.identifier.absfor060408
local.identifier.absfor060403
local.identifier.ariespublicationf5625xPUB3628
local.type.statusPublished Version
local.contributor.affiliationNishimoto, Masazumi, Saitama Medical University, Japan
local.contributor.affiliationKatano, Miyuki, Saitama Medical University, Japan
local.contributor.affiliationYamagishi, Toshiyuki, Osaka City University, Japan
local.contributor.affiliationHishida, Tomoaki, Saitama Medical University, Japan
local.contributor.affiliationKamon, Masayoshi, Saitama Medical University, Japan
local.contributor.affiliationSuzuki, Ayumu, Saitama Medical University, Japan
local.contributor.affiliationHirasaki, Masataka, Saitama Medical University, Japan
local.contributor.affiliationNabeshima, Yoko, Foundation for Biomedical Research and Innovation, Japan
local.contributor.affiliationNabeshima, Yo-ichi, Foundation for Biomedical Research and Innovation, Japan
local.contributor.affiliationKatsura, Yukako, The Graduate University for Advanced Studies (Sokendai), Japan
local.contributor.affiliationSatta, Yoko, The Graduate University for Advanced Studies (Sokendai), Japan
local.contributor.affiliationDeakin, Janine, College of Medicine, Biology and Environment, CMBE Research School of Biology, Division of Evolution, Ecology & Genetics, The Australian National University
local.contributor.affiliationGraves, Jennifer, College of Medicine, Biology and Environment, CMBE Research School of Biology, Division of Evolution, Ecology & Genetics, The Australian National University
local.contributor.affiliationKuroki, Yoko, Laboratory for Immunogenomics, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Kanagawa, Japan,
local.contributor.affiliationOno, Ryuichi, Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, Japan
local.contributor.affiliationIshino, Fumitoshi, Department of Epigenetics, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, Japan
local.contributor.affiliationEma, Masatsugu, Department of Anatomy and Embryology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
local.contributor.affiliationTakahashi, Satoru, Department of Anatomy and Embryology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba andCore Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
local.contributor.affiliationKato, Hidemasa, Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, Yamane Hidaka, Saitama, Japan
local.contributor.affiliationOkuda, Akihiko, Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, Yamane Hidaka, Saitama, Japan and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi, Saitama, Japan
local.identifier.essn1932-6203
local.bibliographicCitation.issue7
local.bibliographicCitation.startpagee68119
local.identifier.doi10.1371/journal.pone.0068119
local.identifier.absseo970106
dc.date.updated2015-12-11T08:16:32Z
local.identifier.scopusID2-s2.0-84879991010
local.identifier.thomsonID000321736900060
CollectionsANU Research Publications

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