In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1
Nishimoto, Masazumi; Katano, Miyuki; Yamagishi, Toshiyuki; Hishida, Tomoaki; Kamon, Masayoshi; Suzuki, Ayumu; Hirasaki, Masataka; Nabeshima, Yoko; Nabeshima, Yo-ichi; Katsura, Yukako; Satta, Yoko; Deakin, Janine E.; Graves, Jennifer A. Marshall; Kuroki, Yoko; Ono, Ryuichi; Ishino, Fumitoshi; Ema, Masatsugu; Takahashi, Satoru; Kato, Hidemasa; Okuda, Akihiko
Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal...[Show more]
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