Skip navigation
Skip navigation

In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1

Nishimoto, Masazumi; Katano, Miyuki; Yamagishi, Toshiyuki; Hishida, Tomoaki; Kamon, Masayoshi; Suzuki, Ayumu; Hirasaki, Masataka; Nabeshima, Yoko; Nabeshima, Yo-ichi; Katsura, Yukako; Satta, Yoko; Deakin, Janine E.; Graves, Jennifer A. Marshall; Kuroki, Yoko; Ono, Ryuichi; Ishino, Fumitoshi; Ema, Masatsugu; Takahashi, Satoru; Kato, Hidemasa; Okuda, Akihiko

Description

Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal...[Show more]

CollectionsANU Research Publications
Date published: 2013-07-09
Type: Journal article
URI: http://hdl.handle.net/1885/16674
Source: PLoS ONE
DOI: 10.1371/journal.pone.0068119

Download

File Description SizeFormat Image
01_Nishimoto_In_Vivo_Function_and_Evolution_2013.pdfPublished Version3.41 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator