In Vivo Function and Evolution of the Eutherian-Specific Pluripotency Marker UTF1
Download (3.41 MB)
-
Altmetric Citations
Nishimoto, Masazumi; Katano, Miyuki; Yamagishi, Toshiyuki; Hishida, Tomoaki; Kamon, Masayoshi; Suzuki, Ayumu; Hirasaki, Masataka; Nabeshima, Yoko; Nabeshima, Yo-ichi; Katsura, Yukako; Satta, Yoko; Deakin, Janine E.; Graves, Jennifer A. Marshall; Kuroki, Yoko; Ono, Ryuichi; Ishino, Fumitoshi; Ema, Masatsugu; Takahashi, Satoru; Kato, Hidemasa; Okuda, Akihiko
Description
Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene expressed in both cell lineages. Here, we analyzed the consequence of loss of the UTF1 gene during mouse development. We found that homozygous UTF1 mutant newborn mice were significantly smaller than wild-type or heterozygous mutant mice, suggesting that placental insufficiency caused by the loss of UTF1 expression in extra-embryonic ectodermal...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2013-07-09 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16674 |
Source: | PLoS ONE |
DOI: | 10.1371/journal.pone.0068119 |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Nishimoto_In_Vivo_Function_and_Evolution_2013.pdf | Published Version | 3.41 MB | Adobe PDF |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator