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Structural Investigation of MscL Gating Using Experimental Data and Coarse Grained MD Simulations

Deplazes, Evelyne; Louhivuori, Martti; Jayatilaka, Dylan; Marrink, Siewert J.; Corry, Ben


The mechanosensitive channel of large conductance (MscL) has become a model system in which to understand mechanosensation, a process involved in osmoregulation and many other physiological functions. While a high resolution closed state structure is available, details of the open structure and the gating mechanism remain unknown. In this study we combine coarse grained simulations with restraints from EPR and FRET experiments to study the structural changes involved in gating with much greater...[Show more]

CollectionsANU Research Publications
Date published: 2012-09-20
Type: Journal article
Source: PLoS Computational Biology
DOI: 10.1371/journal.pcbi.1002683


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