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Deleterious GRM1 Mutations in Schizophrenia

Ayoub, Mohammed Akli; Angelicheva, Dora; Vile, David; Chandler, David; Morar, Bharti; Cavanaugh, Juleen A.; Visscher, Peter M.; Jablensky, Assen; Pfleger, Kevin D. G.; Kalaydjieva, Luba


We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation. GRM1 encodes the metabotropic glutamate receptor 1 (mGluR1), whose documented role as a modulator of neuronal signalling and synaptic plasticity makes it a plausible schizophrenia candidate. In a recent study, this gene was shown to harbour a cluster of deleterious...[Show more]

CollectionsANU Research Publications
Date published: 2012-03-20
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0032849


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