Ayoub, Mohammed Akli; Angelicheva, Dora; Vile, David; Chandler, David; Morar, Bharti; Cavanaugh, Juleen A.; Visscher, Peter M.; Jablensky, Assen; Pfleger, Kevin D. G.; Kalaydjieva, Luba
We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation. GRM1 encodes the metabotropic glutamate receptor 1 (mGluR1), whose documented role as a modulator of neuronal signalling and synaptic plasticity makes it a plausible schizophrenia candidate. In a recent study, this gene was shown to harbour a cluster of deleterious...[Show more]
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