An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid Proteins
Agrawal, Swati; Chung, Duk-Won D.; Ponts, Nadia; van Dooren, Giel G.; Prudhomme, Jacques; Brooks, Carrie F.; Rodrigues, Elisadra M.; Tan, John C.; Ferdig, Michael T.; Striepen, Boris; Le Roch, Karine G.
Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria. There is a constant need for new antimalarials, and one of most keenly pursued drug targets is an ancient algal endosymbiont, the apicoplast. The apicoplast is essential for parasite survival, and several aspects of its metabolism and maintenance have been validated as targets of anti-parasitic drug treatment. Most apicoplast proteins are nuclear...[Show more]
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