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A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus

Horsington, Jacquelyn; Lynn, Helena; Turnbull, Lynne; Cheng, Delfine; Braet, Filip; Diefenbach, Russell J.; Whitchurch, Cynthia B.; Karupiah, Guna; Newsome, Timothy P.


Cell-to-cell transmission of vaccinia virus can be mediated by enveloped virions that remain attached to the outer surface of the cell or those released into the medium. During egress, the outer membrane of the double-enveloped virus fuses with the plasma membrane leaving extracellular virus attached to the cell surface via viral envelope proteins. Here we report that F-actin nucleation by the viral protein A36 promotes the disengagement of virus attachment and release of enveloped virus. Cells...[Show more]

CollectionsANU Research Publications
Date published: 2013-03-21
Type: Journal article
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1003239


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