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Mannose binding lectin is required for alphavirus-induced arthritis/myositis

Gunn, Bronwyn M.; Morrison, Thomas E.; Whitmore, Alan C.; Blevins, Lance K.; Hueston, Linda; Fraser, Robert J.; Herrero, Lara J.; Ramirez, Ruben; Smith, Paul N.; Mahalingam, Suresh; Heise, Mark T.

Description

Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within the muscle and joints, and prior studies have demonstrated that the host complement system contributes to development of disease. In this study, we have used a mouse model of...[Show more]

CollectionsANU Research Publications
Date published: 2012-03-22
Type: Journal article
URI: http://hdl.handle.net/1885/16638
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1002586

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