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An essential role for Katanin p80 and microtubule severing in male gamete production

O'Donnell, Liza; Rhodes, Danielle; Smith, Stephanie J; Merriner, D. Jo; Clark, Brett J; Borg, Claire; Whittle, Belinda; O'Connor, Anne E; Smith, Lee B; McNally, Francis J; de Kretser, David M; Goodnow, Chris C; Ormandy, Chris J; Jamsai, Duangporn; O'Bryan, Moira K

Description

Katanin is an evolutionarily conserved microtubule-severing complex implicated in multiple aspects of microtubule dynamics. Katanin consists of a p60 severing enzyme and a p80 regulatory subunit. The p80 subunit is thought to regulate complex targeting and severing activity, but its precise role remains elusive. In lower-order species, the katanin complex has been shown to modulate mitotic and female meiotic spindle dynamics and flagella development. The in vivo function of katanin p80 in...[Show more]

CollectionsANU Research Publications
Date published: 2012-05-24
Type: Journal article
URI: http://hdl.handle.net/1885/16624
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1002698

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