A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior
Williams, Richard; Lim, Jackie E.; Harr, Bettina; Wing, Claudia; Walters, Ryan; Distler, Margaret G.; Teschke, Meike; Wu, Chunlei; Wiltshire, Tim; Su, Andrew I.; Sokoloff, Greta; Tarantino, Lisa M.; Borevitz, Justin O.; Palmer, Abraham A.
Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a approximately 475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390-30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used it to detect this duplication in 23 of 71 inbred strains tested, and in various...[Show more]
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