Skip navigation
Skip navigation

A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior

Williams, Richard; Lim, Jackie E.; Harr, Bettina; Wing, Claudia; Walters, Ryan; Distler, Margaret G.; Teschke, Meike; Wu, Chunlei; Wiltshire, Tim; Su, Andrew I.; Sokoloff, Greta; Tarantino, Lisa M.; Borevitz, Justin O.; Palmer, Abraham A.

Description

Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a approximately 475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390-30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used it to detect this duplication in 23 of 71 inbred strains tested, and in various...[Show more]

CollectionsANU Research Publications
Date published: 2009-03-06
Type: Journal article
URI: http://hdl.handle.net/1885/16600
Source: PLoS ONE
DOI: 10.1371/journal.pone.0004649

Download

File Description SizeFormat Image
01_Williams_A_common_and_unstable_copy_2009.pdfPublished Version841.69 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator