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High bandwidth synaptic communication and frequency tracking in human neocortex

Testa-Silva, Guilherme; Verhoog, Matthijs B.; Linaro, Daniele; de Kock, Christiaan P. J.; Baayen, Johannes C.; Meredith, Rhiannon M.; De Zeeuw, Chris I.; Giugliano, Michele; Mansvelder, Huibert D.

Description

Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than rodent synapses. To test this, we recorded from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dynamical properties of use-dependent plasticity. We found that human synaptic...[Show more]

CollectionsANU Research Publications
Date published: 2014-11-25
Type: Journal article
URI: http://hdl.handle.net/1885/16559
Source: PLoS Biology
DOI: 10.1371/journal.pbio.1002007

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