Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
The discovery of genes essential for normal T cell numbers and T cell-mediated immune responses provides valuable insights into the adaptive immune system and targets for modulating disorders of immunity in cancer, transplantation, infection and autoimmunity. The studies presented in this thesis investigate two novel gene mutations that diminish the number of circulating T cells. The mutations were discovered by genome-wide ENU-mutagenesis in mice by flow cytometric screening of lymphocyte...[Show more]
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