Effects of glucose and fatty acids interactions on glucose metabolism pathways in human trophoblasts
Introduction: Obesity, with its associated co-morbidities of diabetes, hyperlipidaemia and low-grade inflammation, has high prevalence in women of child-bearing age. Of further concern, it is associated with increased risk of adverse pregnancy outcomes. Considering the key role of the placenta in fetal development, alterations to its structure and function in response to the adverse metabolic milieu of maternal obesity must be important. The trophoblast is a key cell within the placental...[Show more]
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