Diastereoselective Osmium-catalyzed Vicinal Oxyamination of Acyclic Allylic Alcohol Derivatives
The osmium-catalyzed oxyamination of chiral acyclic allylic alcohol derivatives bearing mono- and 1,1-di-substituted double bonds with benzyl N-(4-tosyloxy)carbamate proceeds with high regioselectivity and moderate levels of diastereoselectivity favoring the anti product. The observed stereoselectivity shows a clear and systematic trend with anti:syn ratios increasing in line with the size of substituent at both the allylic stereocenter and double bond alpha-carbon. The stereoinduction is in...[Show more]
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|Masruri et al Diastereoselective Osmium Catalyzed 2013.pdf||156.41 kB||Adobe PDF|
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