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The metabolism of anabolic-androgenic steroids in the greyhound

McKinney, Andrew R; Cawley, Adam T.; Young, E. Bruce; Kerwick, Carmel M.; Cunnington, Karen; Stewart, Rhiannon T.; Ambrus, Joseph I.; Willis, Anthony C.; McLeod, Malcolm D.

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BACKGROUND Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. RESULTS Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol,...[Show more]

dc.contributor.authorMcKinney, Andrew R
dc.contributor.authorCawley, Adam T.
dc.contributor.authorYoung, E. Bruce
dc.contributor.authorKerwick, Carmel M.
dc.contributor.authorCunnington, Karen
dc.contributor.authorStewart, Rhiannon T.
dc.contributor.authorAmbrus, Joseph I.
dc.contributor.authorWillis, Anthony C.
dc.contributor.authorMcLeod, Malcolm D.
dc.date.accessioned2015-11-16T03:43:49Z
dc.date.available2015-11-16T03:43:49Z
dc.identifier.issn1757-6180
dc.identifier.urihttp://hdl.handle.net/1885/16504
dc.description.abstractBACKGROUND Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. RESULTS Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5β- or 3β,5α-stereochemistry, the oxidation of secondary 17β-hydroxyl groups and 16α-hydroxylation. The Phase II β-glucuronylation of sterol metabolites was extensive. CONCLUSION The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples.
dc.description.sponsorshipAustralian Research Council LP0774839
dc.format13 pages
dc.publisherFuture Science
dc.rights© Future Science. http://www.sherpa.ac.uk/romeo/issn/1757-6180/..."author can archive post-print (ie final draft post-refereeing). 12 months for employers website or free public servers in subject areaOn author's personal website, employer's website or institution website or free public servers." from SHERPA/RoMEO site (as at 19/11/15).
dc.sourceBioanalysis
dc.subjectanabolic agents
dc.subjectandrogens
dc.subjectanimals
dc.subjectdogs
dc.subjectdoping in sports
dc.subjectfemale
dc.subjectmale
dc.subjectmodels, animal
dc.subjectsteroids
dc.titleThe metabolism of anabolic-androgenic steroids in the greyhound
dc.typeJournal article
local.identifier.citationvolume5
dc.date.issued2013
local.publisher.urlhttp://www.future-science.com/
local.type.statusAccepted Version
local.contributor.affiliationStewart, R. T., Research School of Chemistry, The Australian National University
local.contributor.affiliationAmbrus, J. I., Research School of Chemistry, The Australian National University
local.contributor.affiliationWillis, A. C., Research School of Chemistry, The Australian National University
local.contributor.affiliationMcLeod, M., Research School of Chemistry, The Australian National University
dc.relationhttp://purl.org/au-research/grants/arc/LP0774839
local.identifier.essn1757-6199
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage769
local.bibliographicCitation.lastpage781
local.identifier.doi10.4155/bio.13.40
CollectionsANU Research Publications

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