The metabolism of anabolic-androgenic steroids in the greyhound
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McKinney, Andrew R; Cawley, Adam T.; Young, E. Bruce; Kerwick, Carmel M.; Cunnington, Karen; Stewart, Rhiannon T.; Ambrus, Joseph I.; Willis, Anthony C.; McLeod, Malcolm D.
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BACKGROUND Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. RESULTS Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol,...[Show more]
dc.contributor.author | McKinney, Andrew R | |
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dc.contributor.author | Cawley, Adam T. | |
dc.contributor.author | Young, E. Bruce | |
dc.contributor.author | Kerwick, Carmel M. | |
dc.contributor.author | Cunnington, Karen | |
dc.contributor.author | Stewart, Rhiannon T. | |
dc.contributor.author | Ambrus, Joseph I. | |
dc.contributor.author | Willis, Anthony C. | |
dc.contributor.author | McLeod, Malcolm D. | |
dc.date.accessioned | 2015-11-16T03:43:49Z | |
dc.date.available | 2015-11-16T03:43:49Z | |
dc.identifier.issn | 1757-6180 | |
dc.identifier.uri | http://hdl.handle.net/1885/16504 | |
dc.description.abstract | BACKGROUND Effective control of the use of anabolic-androgenic steroids (AASs) in animal sports is essential in order to ensure both animal welfare and integrity. In order to better police their use in Australian and New Zealand greyhound racing, thorough metabolic studies have been carried out on a range of registered human and veterinary AASs available in the region. RESULTS Canine metabolic data are presented for the AASs boldenone, danazol, ethylestrenol, mesterolone, methandriol, nandrolone and norethandrolone. The principal Phase I metabolic processes observed were the reduction of A-ring unsaturations and/or 3-ketones with either 3α,5β- or 3β,5α-stereochemistry, the oxidation of secondary 17β-hydroxyl groups and 16α-hydroxylation. The Phase II β-glucuronylation of sterol metabolites was extensive. CONCLUSION The presented data have enabled the effective analysis of AASs and their metabolites in competition greyhound urine samples. | |
dc.description.sponsorship | Australian Research Council LP0774839 | |
dc.format | 13 pages | |
dc.publisher | Future Science | |
dc.rights | © Future Science. http://www.sherpa.ac.uk/romeo/issn/1757-6180/..."author can archive post-print (ie final draft post-refereeing). 12 months for employers website or free public servers in subject areaOn author's personal website, employer's website or institution website or free public servers." from SHERPA/RoMEO site (as at 19/11/15). | |
dc.source | Bioanalysis | |
dc.subject | anabolic agents | |
dc.subject | androgens | |
dc.subject | animals | |
dc.subject | dogs | |
dc.subject | doping in sports | |
dc.subject | female | |
dc.subject | male | |
dc.subject | models, animal | |
dc.subject | steroids | |
dc.title | The metabolism of anabolic-androgenic steroids in the greyhound | |
dc.type | Journal article | |
local.identifier.citationvolume | 5 | |
dc.date.issued | 2013 | |
local.publisher.url | http://www.future-science.com/ | |
local.type.status | Accepted Version | |
local.contributor.affiliation | Stewart, R. T., Research School of Chemistry, The Australian National University | |
local.contributor.affiliation | Ambrus, J. I., Research School of Chemistry, The Australian National University | |
local.contributor.affiliation | Willis, A. C., Research School of Chemistry, The Australian National University | |
local.contributor.affiliation | McLeod, M., Research School of Chemistry, The Australian National University | |
dc.relation | http://purl.org/au-research/grants/arc/LP0774839 | |
local.identifier.essn | 1757-6199 | |
local.bibliographicCitation.issue | 7 | |
local.bibliographicCitation.startpage | 769 | |
local.bibliographicCitation.lastpage | 781 | |
local.identifier.doi | 10.4155/bio.13.40 | |
Collections | ANU Research Publications |
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