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Thiol-reactive analogues of galanthamine, codeine and morphine as potential probes to interrogate allosteric binding within nAChRs

Gallagher, Ryan; Chebib, Mary; Balle, Thomas; McLeod, Malcolm

Description

Alkaloids including galanthamine (1) and codeine (2) are reported to be positive allosteric modulators of nicotinic acetylcholine receptors (nAChRs) but the binding sites responsible for this activity are not known with certainty. Analogues of galanthamine (1), codeine (2) and morphine (3) with reactivity towards cysteine thiols were synthesised including conjugated enone derivatives of the three alkaloids 4-6 and two chloro-alkane derivatives of codeine 7 and 8. The stability of the enones was...[Show more]

CollectionsANU Research Publications
Date published: 2015-10-06
Type: Journal article
URI: http://hdl.handle.net/1885/16502
Source: Australian Journal of Chemistry
DOI: 10.1071/CH15475

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