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Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

Simeonovic, Charmaine; Popp, Sarah; Jensen, Lora; Brown, Debra; Ziolkowski, Andrew; Ludwig, Barbara; Bornstein, Stefan; Wilson, Dennis J; Pugliese, Alberto; Kay, Thomas W.H.; Thomas, Helen E.; Loudovaris, Thomas; Choong, Fui Jiun; Freeman, Craig; Parish, Christopher

Description

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only transiently and partially impacted the disease course, suggesting that other approaches are required. Our previous studies have demonstratedthat heparan sulfate (HS), a glycosaminoglycan conventionally expressed in extracellular matrix, is present at high levels inside normal...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164928
Source: PLOS ONE
DOI: 10.1371/journal.pone.0191360
Access Rights: Open Access

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