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Highly specific gene silencing by artificial miRNAs in rice

Chen, Hao; Warthmann, Norman; Ossowski, Stephan; Weigel, Detlef; Hervé, Philippe


BACKGROUND Endogenous microRNAs (miRNAs) are potent negative regulators of gene expression in plants and animals. Artificial miRNAs (amiRNAs)-designed to target one or several genes of interest-provide a new and highly specific approach for effective post-transcriptional gene silencing (PTGS) in plants. METHODOLOGY We devised an amiRNA-based strategy for both japonica and indica type strains of cultivated rice, Oryza sativa. Using an endogenous rice miRNA precursor and customized 21mers, we...[Show more]

CollectionsANU Research Publications
Date published: 2008-03-19
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0001829


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