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Molecular basis for the folding of beta-helical autotransporter passenger domains

Yuan, Xiaojun; Johnson, Matthew; Zhang, Jing; Lo, Alvin; Schembri, Mark A.; Wijeyewickrema, Lakshmi; Pike, Robert N; Huysmans, Gerard H.M.; Henderson, Ian R; Leyton, Denisse

Description

Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membrane to facilitate translocation of the N-terminal passenger domain to the cell exterior. Once at the surface, the passenger domains of most autotransporters are folded into an elongated β-helix. In a cellular context, key molecules catalyze the assembly of the autotransporter β-barrel domain. However, how the passenger domain folds into its functional form is...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164891
Source: Nature Communications
DOI: 10.1038/s41467-018-03593-2
Access Rights: Open Access

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