Chemoenzymatic Syntheses of Some Analogues of the Tricarbocyclic Core of the Anti-Bacterial Agent Platencin and the Biological Evaluation of Certain of their N-Arylpropionamide Derivatives
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Rehmani, Muhammad; Chang, Ee; Draffan, Alistair; Willis, Anthony; Carr, Paul D; Banwell, Martin
Description
A range of structural variations on the tricarbocyclic core 2 of the anti-bacterial agent platencin 1, including those represented by compounds 14, 15, and 27, have been prepared and certain of these elaborated, through substrate-controlled enolate alkylation reactions, to analogues of the natural product. Preliminary biological evaluation of these analogues revealed that they are only weakly active anti-infective agents.
Collections | ANU Research Publications |
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Date published: | 2018 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/164795 |
Source: | Australian Journal of Chemistry |
DOI: | 10.1071/CH18145 |
Access Rights: | Open Access |
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Chemoenzymatic Syntheses of Some Analogues AAM.pdf | 598.45 kB | Adobe PDF |
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