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Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices

Ponsonby, Anne-Louise; Pezic, Angela; Cameron, Fergus; Rodda, Christine P; Kemp, Andrew; Carlin, John; Hyoty, Heikki; Sioofy-Khojine, Amirbabak; Dwyer, Terence; Ellis, Justine; Craig, Maria

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We aimed to examine the association between parental occupational social contact and hygiene factors on type 1 diabetes (T1D) risk and possible mediation of these effects through child enteroviral infection. We interviewed 333 incident T1D cases and 660 controls from 2008-2011 in Melbourne, Australia. Enteroviral indices (ribonucleic acid by reverse transcription polymerase chain reaction and Coxsackie B virus antibody levels) in peripheral blood were measured in nested case control samples....[Show more]

dc.contributor.authorPonsonby, Anne-Louise
dc.contributor.authorPezic, Angela
dc.contributor.authorCameron, Fergus
dc.contributor.authorRodda, Christine P
dc.contributor.authorKemp, Andrew
dc.contributor.authorCarlin, John
dc.contributor.authorHyoty, Heikki
dc.contributor.authorSioofy-Khojine, Amirbabak
dc.contributor.authorDwyer, Terence
dc.contributor.authorEllis, Justine
dc.contributor.authorCraig, Maria
dc.date.accessioned2019-07-29T06:12:57Z
dc.date.available2019-07-29T06:12:57Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/164774
dc.description.abstractWe aimed to examine the association between parental occupational social contact and hygiene factors on type 1 diabetes (T1D) risk and possible mediation of these effects through child enteroviral infection. We interviewed 333 incident T1D cases and 660 controls from 2008-2011 in Melbourne, Australia. Enteroviral indices (ribonucleic acid by reverse transcription polymerase chain reaction and Coxsackie B virus antibody levels) in peripheral blood were measured in nested case control samples. Parent occupational social contact was assessed by the number of well or sick children, adults or animals contacted daily through work. Higher parental occupational social contact was strongly associated with reduced T1D risk with evidence of dose response (contact with the well or sick score, Adjusted odds ratio (AOR) per category: 0.73 (95% Confidence Interval (CI): 0.66, 0.81); P<0.001 or AOR 0.63 (95% CI: 0.53, 0.75); P<0.001) respectively). Nine of the ten parental social contact indices, were significant mediated through one or more enteroviral indices. The strength of association between enterovirus presence and T1D onset increased with child age (1.2 fold increase per year; P = 0.05). Lower child hand hygiene enhanced the adverse effect of low parental occupational contact with the sick; Synergy Index 5.16 (95% CI: 3.61, 7.36). The interaction between hand washing and parental occupational contact is more consistent with protection against parental enteroviral shedding than the sharing of a protective infectious agent or microbiome.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherPublic Library of Science
dc.rights© 2018 Ponsonby et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePLOS ONE
dc.titleHigher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume13
dc.date.issued2018
local.identifier.absfor111403 - Paediatrics
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationu4485658xPUB2078
local.publisher.urlhttps://www.plos.org/
local.type.statusPublished Version
local.contributor.affiliationPonsonby, Anne-Louise, College of Health and Medicine, ANU
local.contributor.affiliationPezic, Angela, Royal Children's Hospital
local.contributor.affiliationCameron, Fergus, Royal Children's Hospital
local.contributor.affiliationRodda, Christine P, University of Melbourne
local.contributor.affiliationKemp, Andrew, Royal Children’s Hospital
local.contributor.affiliationCarlin, John, Royal Children's Hospital Melbourne
local.contributor.affiliationHyoty, Heikki, School of Medicine
local.contributor.affiliationSioofy-Khojine, Amirbabak, University of Tampere
local.contributor.affiliationDwyer, Terence, Murdoch Children's Research Institute
local.contributor.affiliationEllis, Justine, Royal Children's Hospital
local.contributor.affiliationCraig, Maria, University of New South Wales
local.bibliographicCitation.issue4
local.identifier.doi10.1371/journal.pone.0193992
local.identifier.absseo920104 - Diabetes
dc.date.updated2019-03-31T07:23:07Z
local.identifier.scopusID2-s2.0-85045632000
local.identifier.thomsonID000430262300005
dcterms.accessRightsOpen Access
dc.provenance© 2018 Ponsonby et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.licenseCreative Commons Attribution License
CollectionsANU Research Publications

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