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Genomic atlas of the human plasma proteome

Sun, Benjamin B.; Maranville, Joseph C.; Peters, James E.; Stacey, David; Staley, James R.; Blackshaw, James; Burgess, Stephen; Jiang, Tao; Paige, Ellie; Surendran, Praveen; Oliver-Williams, Clare


Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in healthy blood donors from the INTERVAL study. We identify 1,927 genetic associations with 1,478 proteins, a fourfold increase on existing knowledge, including trans associations for 1,104 proteins....[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Nature
DOI: 10.1038/s41586-018-0175-2


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