Biochemical characterization and chemical inhibition o PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes
The antimalarial activity of chemically diverse compounds, including the clinical candidate cipargamin, has been linked to the ATPase PfATP4 in the malaria-causing parasite Plasmodium falciparum. The characterization of PfATP4 has been hampered by the inability thus far to achieve its functional expression in a heterologous system. Here, we optimized a membrane ATPase assay to probe the function of PfATP4 and its chemical sensitivity. We found that cipargamin inhibited the Na+-dependent ATPase...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Biological Chemistry|
|Access Rights:||Open Access|
|01_Rosling_Biochemical_characterization_2018.pdf||1.35 MB||Adobe PDF|
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