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High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion

Zhang, Can; Liang, Kaili; Zhou, Ding; Yang, Hongjun; Liu, Xin; Yin, Xianze; Xu, Weilin; Zhou, Yingshan; Xiao, Pu

Description

Poly(vinyl alcohol) (PVA) hydrogels have been considered as promising implants for various soft tissue engineering applications because of their tissue-like viscoelasticity and biocompatibility. However, two critical barriers including lack of sufficient mechanical properties and non-tissue-adhesive characterization limit their application as tissue substitutes. Herein, PVA is methacrylated with ultralow degrees of substitution of methacryloyl groups to produce PVA-glycidyl methacrylate (GMA)....[Show more]

dc.contributor.authorZhang, Can
dc.contributor.authorLiang, Kaili
dc.contributor.authorZhou, Ding
dc.contributor.authorYang, Hongjun
dc.contributor.authorLiu, Xin
dc.contributor.authorYin, Xianze
dc.contributor.authorXu, Weilin
dc.contributor.authorZhou, Yingshan
dc.contributor.authorXiao, Pu
dc.date.accessioned2019-07-26T04:44:08Z
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/1885/164736
dc.description.abstractPoly(vinyl alcohol) (PVA) hydrogels have been considered as promising implants for various soft tissue engineering applications because of their tissue-like viscoelasticity and biocompatibility. However, two critical barriers including lack of sufficient mechanical properties and non-tissue-adhesive characterization limit their application as tissue substitutes. Herein, PVA is methacrylated with ultralow degrees of substitution of methacryloyl groups to produce PVA-glycidyl methacrylate (GMA). Subsequently, the PVA-GMA/methacrylate-functionalized silica nanoparticle (MSi)-based nanocomposite hydrogels are developed via the photopolymerization approach. Interestingly, both PVA-GMA-based hydrogels and PVA-GMA/MSi-based nanocomposite hydrogels exhibit outstanding compressive properties, which cannot be damaged through compressive stressstrain tests in the allowable scope of a tensile tester. Moreover, PVA-GMA/MSi-based nanocomposite hydrogels demonstrate excellent tensile properties compared with neat PVA-GMA-based hydrogels, and 15-, 14-, and 24-fold increase in fracture stress, elastic modulus, and toughness, respectively, is achieved for the PVAGMA/MSi-based hydrogels with 10 wt % of MSi. These remarkable enhancements can be ascribed to the amount of long and flexible polymer chains of PVA-GMA and the strong interactions between the MSi and PVA-GMA chains. More interestingly, exciting improvements in the cell adhesion can also be successfully achieved by the incorporation of MSi nanoparticles.
dc.description.sponsorshipThis study was supported by the National Key Research and Development Program of China (no. 2016YFA0101102) and Natural Science Foundation of Hubei Province (no. 2018CFB685). P.X. acknowledges funding from the Australian Research Council Future Fellowship (FT170100301).
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherAmerican Chemical Society
dc.rights© 2018 American Chemical Society
dc.sourceACS Applied Materials and Interfaces
dc.titleHigh-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume10
dc.date.issued2018
local.identifier.absfor030306 - Synthesis of Materials
local.identifier.absfor030399 - Macromolecular and Materials Chemistry not elsewhere classified
local.identifier.ariespublicationu4485658xPUB1719
local.publisher.urlhttps://pubs.acs.org/
local.type.statusPublished Version
local.contributor.affiliationZhang, Can, Ministry of Education
local.contributor.affiliationLiang, Kaili, Wuhan Textile University
local.contributor.affiliationZhou, Ding, Wuhan Textile University
local.contributor.affiliationYang, Hongjun, Wuhan Textile University
local.contributor.affiliationLiu, Xin, Wuhan Textile University
local.contributor.affiliationYin, Xianze, Wuhan Textile University
local.contributor.affiliationXu, Weilin, Wuhan Textile University
local.contributor.affiliationZhou, Yingshan, Wuhan Textile University
local.contributor.affiliationXiao, Pu, College of Science, ANU
local.description.embargo2037-12-31
dc.relationhttp://purl.org/au-research/grants/arc/FT170100301
local.bibliographicCitation.issue33
local.bibliographicCitation.startpage27692
local.bibliographicCitation.lastpage27700
local.identifier.doi10.1021/acsami.8b09026
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2019-03-31T07:22:46Z
local.identifier.scopusID2-s2.0-85051128726
local.identifier.thomsonID000442706600016
CollectionsANU Research Publications

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