Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase
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Seidi, Azadeh; Muellner-Wong, Linden; Rajendran, Esther; Tjhin, Edwin; Dagley, Laura F; Vincent, Aw; Faou, Pierre; Webb, Andrew I.; Tonkin, Christopher J.; van Dooren, Giel
Description
The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full complement of proteins that localize to this organelle has not been defined. Here we undertake two independent approaches to elucidate the mitochondrial proteome of the apicomplexan Toxoplasma gondii. We identify approximately 400 mitochondrial proteins, many of which lack homologs in the animals that these parasites infect, and most of which are important for parasite growth. We demonstrate that...[Show more]
Collections | ANU Research Publications |
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Date published: | 2018 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/164734 |
Source: | eLife |
DOI: | 10.7554/eLife.38131 |
Access Rights: | Open Access |
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01_Seidi_Elucidating_the_mitochondrial_2018.pdf | 4.31 MB | Adobe PDF |
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