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Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase

Seidi, Azadeh; Muellner-Wong, Linden; Rajendran, Esther; Tjhin, Edwin; Dagley, Laura F; Vincent, Aw; Faou, Pierre; Webb, Andrew I.; Tonkin, Christopher J.; van Dooren, Giel

Description

The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full complement of proteins that localize to this organelle has not been defined. Here we undertake two independent approaches to elucidate the mitochondrial proteome of the apicomplexan Toxoplasma gondii. We identify approximately 400 mitochondrial proteins, many of which lack homologs in the animals that these parasites infect, and most of which are important for parasite growth. We demonstrate that...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164734
Source: eLife
DOI: 10.7554/eLife.38131
Access Rights: Open Access

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