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Peptide modification and cyclization via transition-metal catalysis

Malins, Lara


Transition-metal catalysis has unlocked new paradigms for the late-stage modification and cyclization of peptides by harnessing the innate reactivity of proteinogenic amino acids. The field is rapidly evolving, with recent advances encompassing three fundamental areas - heteroatom couplings, decarboxylative cross-couplings, and C-H functionalizations - which have markedly extended the scope of conventional peptide modification and bioconjugation strategies. The advances outlined herein...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Current Opinion in Chemical Biology
DOI: 10.1016/j.cbpa.2018.03.019
Access Rights: Open Access


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