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Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, Mitchell; Obinata, Daisuke; Sandhu, Shahneen; Selth, Luke A; Wong, Stephen Q.; Porter, Laura; Lister, Gordon; Pook, David; Pezaro, Carmel; Goode, David L.; Hannan, Ross

Description

Background The intractability of castration-resistant prostate cancer (CRPC) is exacerbated by tumour heterogeneity, including diverse alterations to the androgen receptor (AR) axis and AR-independent phenotypes. The availability of additional models encompassing this heterogeneity would facilitate the identification of more effective therapies for CRPC. Objective To discover therapeutic strategies by exploiting patient-derived models that exemplify the heterogeneity of CRPC. Design,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164729
Source: European Urology
DOI: 10.1016/j.eururo.2018.06.020

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