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Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii

Uboldi, Alessandro D; Wilde, Mary-Louise; McRae, Emi A; Stewart, Rebecca J; Dagley, Laura F; Yang, Luning; Katris, Nicholas J; Hapuarachchi, Sanduni; Coffey, Michael J; Lehane, Adele; Botte, Cyrille Y; Waller, Ross F


The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+ signalling activates motility, but how this is switched off after invasion is complete to allow for replication to begin is not understood. Here, we show that the cyclic adenosine monophosphate (cAMP)-dependent protein kinase A catalytic subunit 1 (PKAc1) of Toxoplasma is...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: PLoS Biology
DOI: 10.1371/journal.pbio.2005642
Access Rights: Open Access


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