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Identification of genes which regulate stromadependent in vitro hematopoiesis

Periasamy, Pravin; Tran, Vinson; O'Neill, Helen C

Description

Cultured splenic stroma has been shown to support in vitro hematopoiesis in overlaid bone marrow and spleen progenitors. These co-cultures support longterm production of a novel dendritic-like cell type along with transient production of myeloid cells. They also maintain a progenitor cell population. The splenic stromal lines 5G3 and 3B5 have been identified as a supporter and a non-supporter of hematopoiesis. Based on their gene expression profile, both 5G3 and 3B5 express genes related to...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164720
Source: PLOS ONE
DOI: 10.1371/journal.pone.0205583
Access Rights: Open Access

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