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Infliximab reverses inflammatory muscle wasting (sarcopenia) in Crohn's disease

Subramaniam, Kavitha; Fallon, Kieran; Ruut, Tom; Lane, D; McKay, R.; Shadbolt, Bruce; Ang, S.; Cook, Matthew; Platten, J.; Pavli, Paul; Taupin, Douglas

Description

Background Muscle wasting or sarcopenia arising from chronic inflammation is found in 60% of patients with Crohn's disease. Transcriptional protein NF-κB reduces muscle formation through MyoD transcription and increases muscle breakdown by proteolysis. Aim As TNF is a potent activator of NF-κB, and anti-TNF agent infliximab (IFX) prevents NF-κB activation, to determine whether or not Crohn's patients treated with IFX gain muscle volume and strength. Methods We performed a...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/164703
Source: Alimentary pharmacology & therapeutics
DOI: 10.1111/apt.13058

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