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Monitoring Early-Stage Protein Aggregation by an Aggregation-Induced Emission Fluorogen

Kumar, Manjeet; Hong, Yuning; Thorn, David; Ecroyd, Heath; Carver, John

Description

Highly ordered protein aggregates, termed amyloid fibrils, are associated with a broad range of diseases, many of which are neurodegenerative, for example, Alzheimer’s and Parkinson’s. The transition from soluble, functional protein into insoluble amyloid fibril occurs via a complex process involving the initial generation of highly dynamic early stage aggregates or prefibrillar species. Amyloid probes, for example, thioflavin T and Congo red, have been used for decades as the gold standard for...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/164700
Source: Analytical Chemistry
DOI: 10.1021/acs.analchem.7b02090

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