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Dimeric Fc-R ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia

Wines, Bruce D.; Tan, C.W.; Duncan, E; McRae, S; Baker, R.I.; Andrews, R.K.; Esparon, S; Gardiner, Elizabeth; Hogarth, P.M.


Background Heparin‐induced thrombocytopenia (HIT) is a major and potentially fatal consequence of antibodies produced against platelet factor 4 (PF4)–heparin complexes following heparin exposure. Not all anti‐PF4–heparin antibodies are pathogenic, so overdiagnosis can occur, with resulting inappropriate use of alternative anticoagulation therapies that have associated risks of bleeding. However, definitive platelet functional assays are not widely available for routine...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Journal of Thrombosis and Haemostasis
DOI: 10.1111/jth.14306
Access Rights: Open Access


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