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Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina

Rutar, Matt; Valter, Krisztina; Natoli, Riccardo; Provis, Jan M.


INTRODUCTION Complement activation is thought to contribute to the pathogenesis of age-related macular degeneration (AMD), which may be mediated in part by para-inflammatory processes. We aimed to investigate the expression and localization of C3, a crucial component of the complement system, in the retina during the course of aging. METHODS SD rats were born and reared in low-light conditions, and euthanized at post-natal (P) days 100, 450, or 750. Expression of C3, IBA1, and Ccl- and Cxcl-...[Show more]

CollectionsANU Research Publications
Date published: 2014-04-04
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0093343


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