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Regulation of endothelial-specific transgene expression by the LacI repressor protein in vivo

Morton, Susan K.; Chaston, Daniel J.; Baillie, Brett; Hill, Caryl E.; Matthaei, Klaus I.


Genetically modified mice have played an important part in elucidating gene function in vivo. However, conclusions from transgenic studies may be compromised by complications arising from the site of transgene integration into the genome and, in inducible systems, the non-innocuous nature of inducer molecules. The aim of the present study was to use the vascular system to validate a technique based on the bacterial lac operon system, in which transgene expression can be repressed and...[Show more]

CollectionsANU Research Publications
Date published: 2014-04-22
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0095980


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