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IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages

Sheng, Kuo-Ching; Herrero, Lara J.; Taylor, Adam; Hapel, Andrew J.; Mahalingam, Suresh


Unraveling the mechanisms of hematopoiesis regulated by multiple cytokines remains a challenge in hematology. IL-3 is an allergic cytokine with the multilineage potential, while CSF-1 is produced in the steady state with restricted lineage coverage. Here, we uncovered an instructive role of CSF-1 in IL-3-mediated hematopoiesis. CSF-1 significantly promoted IL-3-driven CD11c+ cell expansion and dampened basophil and mast cell generation from C57BL/6 bone marrow. Further studies indicated that...[Show more]

CollectionsANU Research Publications
Date published: 2014-04-17
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0095208


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