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Mechanism of μ-Conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4

Chen, Rong; Robinson, Anna; Chung, Shin-Ho


Several subtypes of voltage-gated Na+ (NaV) channels are important targets for pain management. μ-Conotoxins isolated from venoms of cone snails are potent and specific blockers of different NaV channel isoforms. The inhibitory effect of μ-conotoxins on NaV channels has been examined extensively, but the mechanism of toxin specificity has not been understood in detail. Here the known structure of μ-conotoxin PIIIA and a model of the skeletal muscle channel NaV1.4 are used to elucidate elements...[Show more]

CollectionsANU Research Publications
Date published: 2014-03-27
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0093267


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