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DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation

Ainalem, Marie-Louise; Bartles, Andrew; Muck, Joscha; Dias, Rita S.; Carnerup, Anna M.; Zink, Daniele; Nylander, Tommy

Description

There is an increasing interest in achieving gene regulation in biotechnological and biomedical applications by using synthetic DNA-binding agents. Most studies have so far focused on synthetic sequence-specific DNA-binding agents. Such approaches are relatively complicated and cost intensive and their level of sophistication is not always required, in particular for biotechnological application. Our study is inspired by in vivo data that suggest that DNA compaction might contribute to gene...[Show more]

CollectionsANU Research Publications
Date published: 2014-03-26
Type: Journal article
URI: http://hdl.handle.net/1885/16460
Source: PLoS ONE
DOI: 10.1371/journal.pone.0092692

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