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Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between MicroRNAs and their target mRNAs

Yang, Ming; Eyers, Fiona; Xiang, Yang; Guo, Man; Young, Ian G.; Rosenberg, Helene F.; Foster, Paul S.

Description

BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs that regulate complex transcriptional networks underpin immune responses. However, little is known about the specific miRNA networks that control differentiation of specific leukocyte subsets. In this study, we profiled miRNA expression during differentiation of eosinophils from bone marrow (BM) progenitors (bmEos), and correlated expression with potential mRNA targets involved in crucial regulatory functions. Profiling was performed on...[Show more]

CollectionsANU Research Publications
Date published: 2014-05-13
Type: Journal article
URI: http://hdl.handle.net/1885/16456
Source: PLoS ONE
DOI: 10.1371/journal.pone.0097537

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