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Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

Man, Si Ming


Inflammasome signalling is an emerging pillar of innate immunity and has a central role in the regulation of gastrointestinal health and disease. Activation of the inflammasome complex mediates both the release of the pro-inflammatory cytokines IL-1β and IL-18 and the execution of a form of inflammatory cell death known as pyroptosis. In most cases, these mediators of inflammation provide protection against bacterial, viral and protozoal infections. However, unchecked inflammasome activities...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Nature Reviews. Gastroenterology & Hepatology
DOI: 10.1038/s41575-018-0054-1


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