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Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

Tjhin, Erick; Spry, Christina; Sewell, Alan L; Hoegl, Annabelle; Barnard, Leanne; Sexton, Anna E; Siddiqui, Ghizal; Howieson, Vanessa; Maier, Alex; Creek, Darren J; Strauss, Erick; Marquez, Rodolfo; Auclair, Karine; Saliba, Kevin

Description

The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antiplasmodial pantothenate analogues, including pantothenol and CJ-15,801, kill the parasite by targeting CoA biosynthesis/utilisation. Their mechanism of action, however, remains unknown. Here, we show that parasites pressured with pantothenol or...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164547
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1006918
Access Rights: Open Access

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