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Obesity-induced metabolic disturbance drives oxidative stress and complement activation in the retinal environment

Natoli, Riccardo; Fernando, Nilisha; Dahlenburg, Tess; Jiao, Haihan; Aggio-Bruce, Riemke; Barnett, Nigel L; Chao De La Barca, Juan; Tcherkez, Guillaume; Reynier, Pascal; Chu-Tan, Joshua; Valter, Krisztina; Provis, Jan; Rutar, Matthew


Purpose Systemic increases in reactive oxygen species, and their association with inflammation, have been proposed as an underlying mechanism linking obesity and age-related macular degeneration (AMD). Studies have found increased levels of oxidative stress biomarkers and inflammatory cytokines in obese individuals; however, the correlation between obesity and retinal inflammation has yet to be assessed. We used the leptin-deficient (ob/ob) mouse to further our understanding of the...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Molecular Vision
Access Rights: Open Access


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