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Four-Step Total Synthesis of Selaginpulvilin D

Sherburn, Michael; Sowden, Madison

Description

An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/164502
Source: Organic Letters
DOI: 10.1021/acs.orglett.6b03793

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