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Prevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden

Sheikh, Faisal; Ismail, Zahinoor; Mortby, Moyra; Barber, Philip; Cieslak, Alicja; Fischer, Karyn; Granger, Robert; Hogan, David B; Mackie, Aaron; Maxwell, J, Colleen

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Background: Mild behavioral impairment (MBI) describes later life acquired, sustained neuropsychiatric symptoms (NPS) in cognitively normal individuals or those with mild cognitive impairment (MCI), as an at-risk state for incident cognitive decline and dementia. We developed an operational definition of MBI and tested whether the presence of MBI was related to caregiver burden in patients with subjective cognitive decline (SCD) or MCI assessed at a memory clinic. Methods: MBI was assessed...[Show more]

dc.contributor.authorSheikh, Faisal
dc.contributor.authorIsmail, Zahinoor
dc.contributor.authorMortby, Moyra
dc.contributor.authorBarber, Philip
dc.contributor.authorCieslak, Alicja
dc.contributor.authorFischer, Karyn
dc.contributor.authorGranger, Robert
dc.contributor.authorHogan, David B
dc.contributor.authorMackie, Aaron
dc.contributor.authorMaxwell, J, Colleen
dc.date.accessioned2019-07-08T23:18:58Z
dc.identifier.issn1041-6102
dc.identifier.urihttp://hdl.handle.net/1885/164400
dc.description.abstractBackground: Mild behavioral impairment (MBI) describes later life acquired, sustained neuropsychiatric symptoms (NPS) in cognitively normal individuals or those with mild cognitive impairment (MCI), as an at-risk state for incident cognitive decline and dementia. We developed an operational definition of MBI and tested whether the presence of MBI was related to caregiver burden in patients with subjective cognitive decline (SCD) or MCI assessed at a memory clinic. Methods: MBI was assessed in 282 consecutive memory clinic patients with SCD (n = 119) or MCI (n = 163) in accordance with the International Society to Advance Alzheimer's Research and Treatment – Alzheimer's Association (ISTAART–AA) research diagnostic criteria. We operationalized a definition of MBI using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Caregiver burden was assessed using the Zarit caregiver burden scale. Generalized linear regression was used to model the effect of MBI domains on caregiver burden. Results: While MBI was more prevalent in MCI (85.3%) than in SCD (76.5%), this difference was not statistically significant (p = 0.06). Prevalence estimates across MBI domains were affective dysregulation (77.8%); impulse control (64.4%); decreased motivation (51.7%); social inappropriateness (27.8%); and abnormal perception or thought content (8.7%). Affective dysregulation (p = 0.03) and decreased motivation (p=0.01) were more prevalent in MCI than SCD patients. Caregiver burden was 3.35 times higher when MBI was present after controlling for age, education, sex, and MCI (p < 0.0001). Conclusions: MBI was common in memory clinic patients without dementia and was associated with greater caregiver burden. These data show that MBI is a common and clinically relevant syndrome.
dc.description.sponsorshipWe would like to acknowledge the support of the Ron and Irene Ward foundation, the Taylor family foundation, the Clinician Engagement Grant from the Addiction and Mental Health Strategic Clinical Network of Alberta Health Services, and the Alzheimer’s Society of Calgary, via the Hotchkiss Brain Institute. M. E. Mortby is supported by the Australian National Health and Medical Research Council (NHMRC) and Australian Research Council (ARC) Dementia Research Development Fellowship #1102028.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherSpringer
dc.rights© 2017 International Psychogeriatric Association
dc.sourceInternational Psychogeriatrics
dc.subjectmild behavioral impairment (MBI)
dc.subjectmild cognitive impairment (MCI)
dc.subjectcaregiver burden
dc.subjectsubjective cognitive decline
dc.subjectmemory clinic
dc.subjectprodromal dementia
dc.titlePrevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume30
dc.date.issued2017-09-07
local.identifier.absfor110308 - Geriatrics and Gerontology
local.identifier.absfor111702 - Aged Health Care
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationa383154xPUB10410
local.type.statusPublished Version
local.contributor.affiliationSheikh, Faisal, Department of Psychiatry
local.contributor.affiliationIsmail, Zahinoor, University of Calgary
local.contributor.affiliationMortby, Moyra, College of Health and Medicine, ANU
local.contributor.affiliationBarber, Philip, Department of Clinical Neurosciences
local.contributor.affiliationCieslak, Alicja, Department of Clinical Neurosciences, and The Ron and Rene Ward Centre for Healthy Brain Aging Research, Hotchkiss Brain Institute, University of Calgary
local.contributor.affiliationFischer, Karyn, Ron and Rene Ward Centre for Healthy Brain Aging Research
local.contributor.affiliationGranger, Robert, Department of Psychiatry
local.contributor.affiliationHogan, David B, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary
local.contributor.affiliationMackie, Aaron, Department of Psychiatry
local.contributor.affiliationMaxwell, J, Colleen, Department of Community Health Sciences
local.description.embargo2037-12-31
dc.relationhttp://purl.org/au-research/grants/nhmrc/1102028
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage233
local.bibliographicCitation.lastpage244
local.identifier.doi10.1017/S104161021700151X
local.identifier.absseo920502 - Health Related to Ageing
local.identifier.absseo920202 - Carer Health
local.identifier.absseo920410 - Mental Health
dc.date.updated2022-05-15T08:16:04Z
local.identifier.scopusID2-s2.0-85049640783
local.identifier.thomsonIDWOS:000438379800008
CollectionsANU Research Publications

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