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MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis

Petvises, Sawang; Periasamy, Pravin; O'Neill, Helen


Background: Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations of cells, characterised as CD11b+CD11c+MHC-II− dendritic-like ‘L-DC’, and CD11b+CD11c+ MHC-II+ cells, resembling conventional dendritic cells (cDC). To date, the functional capacity of these two subsets has not been clearly distinguished. Results:...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: BMC Immunology
DOI: 10.1186/s12865-018-0255-y
Access Rights: Open Access


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