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Adverse drug event-related hospitalisation in persons with neurodevelopmental disorders: a state-wide retrospective cohort study

Zhou, Mingming; Du, Wei; Salvador-Carulla, Luis; Glasgow, Nicholas

Description

Background Little is known about the sociodemographic and clinical characteristics of adverse drug events (ADEs) in patients with neurodevelopmental disorders (NDD). Objective The objective of this study was to describe and compare the demographic details of people with and without NDD hospitalised due to ADEs. Methods The all‐inclusive New South Wales Admitted Patient Data Collection from 2001 to 2014 was employed to identify ADE‐related hospitalisations in patients with NDD using the...[Show more]

dc.contributor.authorZhou, Mingming
dc.contributor.authorDu, Wei
dc.contributor.authorSalvador-Carulla, Luis
dc.contributor.authorGlasgow, Nicholas
dc.date.accessioned2019-06-24T05:57:46Z
dc.identifier.issn0964-2633
dc.identifier.urihttp://hdl.handle.net/1885/164181
dc.description.abstractBackground Little is known about the sociodemographic and clinical characteristics of adverse drug events (ADEs) in patients with neurodevelopmental disorders (NDD). Objective The objective of this study was to describe and compare the demographic details of people with and without NDD hospitalised due to ADEs. Methods The all‐inclusive New South Wales Admitted Patient Data Collection from 2001 to 2014 was employed to identify ADE‐related hospitalisations in patients with NDD using the International Classification of Diseases 10th revision Australian modification codes. We derived case sets specific to different clinical groups and patient characteristics and compared proportional differences between patients with and without intellectual disability using chi squared tests. Results A total of 2173 patients with NDD were admitted for acute care of ADEs, accounting for 0.7% of all ADE‐related hospitalisations. Hospitalised ADEs among patients with NDD increased by twofold over the 14‐year study period. Psychotropic medications and opioid analgesic medications were leading causes of ADE‐related hospitalisations in patients with NDD. Compared with their counterparts, patients with NDD were younger, experienced more socio‐economic disadvantage and less private insurance coverage, suffered with less severe but different co‐morbid clinical conditions and incurred more challenges in the acute hospital care setting. Conclusion Although the pattern of ADE‐related hospitalisations in patients with NDD differed from that in patients without NDD, there is a lack of targeted healthcare programmes to meet their special needs. This study suggests the need for countermeasures in primary healthcare settings to reduce the burden of ADEs in this vulnerable group.
dc.description.sponsorshipThis study was supported by the NHMRC CREMA Q16 Small Project Grants scheme. M. Z. is supported by the Chinese Scholarship Council affiliated with the Ministry of Education of the P.R. China.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherBlackwell Publishing Ltd
dc.rights© 2019 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities andJohn Wiley & Sons Ltd
dc.sourceJournal of Intellectual Disability Research
dc.subjectadverse drug events
dc.subjecthospital care
dc.subjectneurodevelopmental disorders
dc.subjecttherapeutic medications
dc.titleAdverse drug event-related hospitalisation in persons with neurodevelopmental disorders: a state-wide retrospective cohort study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume63
dc.date.issued2019
local.identifier.absfor110904 - Neurology and Neuromuscular Diseases
local.identifier.ariespublicationu5786633xPUB740
local.type.statusPublished Version
local.contributor.affiliationZhou, Mingming, College of Health and Medicine, ANU
local.contributor.affiliationDu, Wei, College of Health and Medicine, ANU
local.contributor.affiliationSalvador-Carulla, Luis, College of Health and Medicine, ANU
local.contributor.affiliationGlasgow, Nicholas, College of Health and Medicine, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage429
local.bibliographicCitation.lastpage440
local.identifier.doi10.1111/jir.12586
local.identifier.absseo920205 - Health Education and Promotion
dc.date.updated2019-06-23T08:18:04Z
local.identifier.scopusID2-s2.0-85059527903
CollectionsANU Research Publications

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