Characterising negative regulation of CD8+ T cell function in tolerance and exhaustion
CD8+ T cells play a vital role in the immune system by clearing pathogen-infected tissues, however self-reactive CD8+ T cells that escape thymic selection pose the danger of causing autoimmune disease. These self-reactive CD8+ T cells are controlled in the periphery by tolerance mechanisms, which inhibit their function (anergy) or induce apoptosis (deletion). However, the specific molecular pathways crucial for negatively regulating self-reactive CD8+ T cells are not well elucidated. A distinct...[Show more]
|Collections||Open Access Theses|
|Mayura Wagle- PhD Thesis FINAL.pdf||Thesis Material||16.13 MB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.