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Characterising negative regulation of CD8+ T cell function in tolerance and exhaustion

Wagle, Mayura


CD8+ T cells play a vital role in the immune system by clearing pathogen-infected tissues, however self-reactive CD8+ T cells that escape thymic selection pose the danger of causing autoimmune disease. These self-reactive CD8+ T cells are controlled in the periphery by tolerance mechanisms, which inhibit their function (anergy) or induce apoptosis (deletion). However, the specific molecular pathways crucial for negatively regulating self-reactive CD8+ T cells are not well elucidated. A distinct...[Show more]

CollectionsOpen Access Theses
Date published: 2019
Type: Thesis (PhD)
DOI: 10.25911/5d7a261572f22


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