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Platelets kill circulating parasites of all major Plasmodium species in human malaria

Kho, Steven; Barber, Bridget E.; Johar, Edison; Andries, Benediktus; Poespoprodjo, Jeanne R.; Kenangalem, Enny; Piera, Kim E; Ehmann, Anna; Price, Ric N; William, Timothy; Woodberry, Tonia; Foote, Simon; Minigo, Gabriela; Yeo, Tsin W.; Grigg, Matthew J.; Anstey, Nicholas; McMorran, Brendan


Platelets are understood to assist host innate immune responses against infection, although direct evidence of this function in any human disease, including malaria, is unknown. Here we characterized platelet–erythrocyte interactions by microscopy and flow cytometry in patients with malaria naturally infected with Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, or Plasmodium knowlesi. Blood samples from 376 participants were collected from malaria-endemic areas of Papua,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2018-05-849307
Access Rights: Open Access


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