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Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Mikusek, Jiri; Nugent, Jeremy; Lan, Ping; Banwell, Martin


In 2002, Hirota and co-workers reported(1) the isolation and structural elucidation of a series of anti-inflammatory agents, named myrsinoic acids, from the fresh leaves and twigs of Myrsine seguinii, a hardwood of the Myrsinaceae family found in various parts of Asia from Myanmar to Japan. The most active of these compounds was myrsinoic acid F (MA-F) and to which structure 1 (Figure 1) was assigned(1) on the basis of a range of NMR spectroscopic and mass spectrometric studies. This compound...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Journal of Natural Products
DOI: 10.1021/acs.jnatprod.8b00778


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